Nucleo forte us version12/18/2022 ![]() ![]() ![]() Nucleotides play a central role in many cellular processes, including those associated with nerve repair and drugs containing nucleotides such as Nucleo-CMP Forte ® (NCF) have been prescribed to patients with peripheral neurological conditions. It has been reported that conjugated linoleic acid (CLA) gives PSO its favorable physiological antioxidant and anti-inflammatory properties, including anti-atherosclerosis, antiobesity, anti-tumor, and antiaging, inhibiting expression of proinflammatory cytokines, and boosting immune system. Pomegranate seed oil (PSO) represents a rich source of polyunsaturated fatty acids, especially linoleic and punicic acid, polyphenols, phytosterols, and tocopherols. A multitude of molecular and cellular mechanisms have been elucidated for PIPN such as targeting distal neurons, voltage gated ion channels, neurotransmitters, and glial cells, activation of proinflammatory cytokines, neuro-inflammation, and oxidative stress. Paclitaxel-induced peripheral neuropathy (PIPN) is one of the major side effect experienced by patients on paclitaxel (PT) chemotherapy, characterized by the presence of spontaneous pain, hyperalgesia, and allodynia. Protection against paclitaxel-induced hyperalgesia and allodynia by pomegranate seed oil, nucleo-cmp forte ®, and l-carnitine. How to cite this article: Mohammed Ali NA. Keywords: Allodynia, hyperalgesia, L-carnitine, neuropathy, Nucleo-CMP Forte ®, paclitaxel, pomegranate seed oil Conclusion: PSO, NCF, and LC have significant potential anti-nociceptive and analgesic activity against PT-induced NP and PSO was the most efficacious than NCF and LC. ![]() Results: PSO, NCF, and LC significantly attenuated NP induced by PT from day 14 up to 28 days using the different behavioral tests for thermal hyperalgesia and allodynia. Different behavior parameters were used to test the anti-hyperalgesic and anti-allodynic effect of PSO, NCF, and LC on days 0, 7, 14, 21, and 28 of PT administration. PSO, NCF, and LC were administered orally once daily to mice with PT-induced neuropathy in their corresponding groups. p., once weekly) to the mice in all groups except C group. NP was induced by the administration of PT (6 mg/kg, i. Materials and Methods: Thirty adult male mice were divided equally into five groups of six mice in each group as follows: Control (C), PT, PSO (PTpso), NCF (PTn), and LC (PTc) groups. The aim of this study is to compare the anti-hyperalgesia and anti-allodynia activity of PSO, NCF, and LC in PT-induced neuropathy. Nucleo-CMP Forte ® (NCF) is a nucleotide-based drug and L-carnitine (LC) is a member of natural compounds have been shown effective in diverse peripheral neuroglial disorders. Pomegranate seed oil (PSO) has been used in the traditional medicine for the different kinds of pain. Background: Hyperalgesia and allodynia are abnormal sensory signs which are usually seen along neuropathic pain (NP) in patients on paclitaxel (PT) chemotherapy. ![]()
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